The STOXX Europe 600 fell 0.3 but the Nikkei 225 rose 0.1 percent.
The US and UK markets were closed for holidays.
European stocks were dragged down by a 2.1 percent plunge in the FTSE MIB after Italian President Sergio Mattarella asked former International Monetary Fund official Carlo Cottarelli to try to form a new government.
On Sunday, Mattarella had blocked the ascent to power of a government supported by the maverick 5 Star Movement and the hard-right League after they proposed a euroskeptic figure as economy minister.
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